QbCon® – Continuous Manufacturing of Tablets
Continuous Manufacturing – Machines and Processes
Continuous Manufacturing for your daily production!
The QbCon® continuous manufacturing line combines all necessary steps for the production from powder to coated tablets. Continuous dosing and mixing, various granulation processes, tableting as well as tablet coating takes place in one single system with an integrated process control concept. The integration of PAT tools such as near-infrared (NIR) or Raman spectroscopy facilitates the inline monitoring of critical quality characteristics of intermediate products as well as the finished product. The integration of control algorithms enables continuous monitoring of the quality of the desired product and enhances product quality.
Depending on the properties of the starting material and the desired properties of the final product, the QbCon® continuous production system enables the production via direct compression, dry granulation, or wet granulation.
Continuous Manufacturing:
Machines and systems for the pharmaceutical tablet production
Wet Granulation
QbCon® WG – Continuous Manufacturing from powder to coated tablets via Wet Granulation
Dosing / Feeding
Blending
Wet Granulation
Drying
Dosing / Feeding
Blending
Tableting
Tablet Coating
Dosing / Feeding
Blending
Wet Granulation
Drying
Dosing / Feeding
Blending
Tableting
Tablet Coating
Dry Granulation / Roller Compacting
QbCon® DG – Continuous Manufacturing from powder to coated tablets via Dry Granulation / Roller Compaction
Dosing / Feeding
Blending
Dry Granulation
Dosing / Feeding
Blending
Tableting
Tablet Coating
Dosing / Feeding
Blending
Dry Granulation
Dosing / Feeding
Blending
Tableting
Tablet Coating
Direct compression
QbCon® DC – Continuous Manufacturing from powder to coated tablets via Direct Compression
Dosing / Feeding
Blending
Tableting
Tablet Coating
Dosing / Feeding
Blending
Tableting
Tablet Coating
Contact us to learn more about our continuous manufacturing systems
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Our machines and systems for
continuous manufacturing
BRC – Dry Granulator / Roller Compactor
The dry granulator BRC is predominantly used to produce large-volume or moisture-intensive products. The BRC enables high-production capacity with minimal loss of material. This is achieved by fast and precise control of the compaction force with a new electromechanical spindle drive for the two rollers. In combination with a sensitive control of the variable gap via the screw feeding system, constant ribbon properties are assured over a wide production range from <1kg up to 400kg/h.
Advantages
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Integrated WIP nozzles ensure fast and effective cleaning -
BTS Sieve guarantees versatile and gentle particle size calibration -
PAT integration -
Optional containment execution
BCG – Twin-screw Granulator
The BCG twin-screw granulator and BCD continuous dryer are the decisive factors for truly continuous wet granulation and drying. Fully integrated into the QbCon® manufacturing line or as a stand-alone machine, the twin-screw granulator is the optimal machine for the introduction of continuous granulation.
Advantages
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Mixing and granulation in one step and in the shortest possible time -
Short residence times of the material in the process -
100 % in-line quality control possible -
Product of inferior quality can be selectively rejected -
Optimal for rapid product development
BCD – Continuous fluidized-bed dryer
The BCD is the perfect system for the truly continuous drying of granules. Successfully used in research and development as well as in the production of large quantities, the patented product filters guarantee operation for days. This means that the continuous granulation process does not have to be interrupted. The continuous fluidized-bed dryer is available in various sizes.
Advantages
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No formation of sub-batches -
No process interruption – very long product filter service life -
Uniform drying across all particle sizes -
Discharge of poor product possible -
Very fast product development
KOCO® – Semi-Continuous Tablet Coater
Built on the industry proven design of all L.B. Bohle Coaters, the KOCO® semi-continuous coater guarantees best class and problem-free tablet coating. The KOCO® stands out with a reliable throughput while ensuring a constant residence time of all cores. Due to the design advantages of the coating pan, air duct and spray system, the KOCO® can repetitively execute the coating cycle, without affecting the process and product quality .
Advantages
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Excellent process control and product processing -
Best coating uniformity -
Lowest suspension losses -
Process analysis via Raman spectroscopy -
Containment execution is an option
QbCon® 1
The first step towards continuous manufacturing often takes place in research and development. With QbCon® 1, L.B. Bohle presents the optimal system for continuous wet granulation and drying. Space-saving and suitable for lowest throughput (nominal throughput: 0.5-2.5 kg/h), QbCon®1 meets all quality requirements of a pharmaceutical production, such as short residence time of the granules in the dryer with simultaneous narrow residence time distribution.
Advantages
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Uniform conveying of the granules from feeding to discharge -
Production of granules of different porosity -
Effective, gentle, and uniform drying -
Fully automatic filter cleaning during the drying process -
Secured scale-up – fast product development
Your contact for
Continuous Manufacturing
Burkhard Schmidt
Sales Director
inquiry@lbbohle.de
+49 2524 – 93 23 0
